Ischemic Preconditioning in the Intact Rat Heart Is Mediated by delta1- But Not [micro sign]- or kappa-Opioid Receptors

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Abstract

Background

Our laboratory has previously shown that delta-opioid receptors are involved in the cardioprotective effect of ischemic preconditioning in the rat heart. However, this class of receptors consists of two subtypes, delta (1) and delta2, and [micro sign]- or kappa-opioid receptors may also exist in the heart. Therefore, the purpose of the present study was to test the hypothesis that ischemic preconditioning is mediated through stimulation of one or both delta-opioid receptor subtypes.

Conclusions

These results indicate that delta1-opioid receptors play an important role in the cardioprotective effect of ischemic preconditioning in the rat heart. (Circulation. 1998;97:1282-1289.)

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