Association Between Body Iron Stores and the Risk of Acute Myocardial Infarction in Men

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Epidemiological evidence concerning the role of iron, a lipid peroxidation catalyst, in coronary heart disease (CHD) is inconsistent. We investigated the association of the concentration ratio of serum transferrin receptor to serum ferritin (TfR/ferritin), a state-of-the-art measurement of body iron stores, with the risk of acute myocardial infarction (AMI) in a prospective nested case-control study in men from eastern Finland.


These data show an association between increased body iron stores and excess risk of AMI, confirming previous epidemiological findings. (Circulation. 1998;97:1461-1466.)

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