Recombinant Cardiac ATP-Sensitive K+ Channel Subunits Confer Resistance To Chemical Hypoxia-Reoxygenation Injury

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Abstract

Background

Opening of cardiac ATP-sensitive K+ (KATP) channels has emerged as a promising but still controversial cardioprotective mechanism. Defining KATP channel function at the level of recombinant channel proteins is a necessary step toward further evaluation of the cardioprotective significance of this ion conductance.

Conclusions

The fact that transfer of cardiac KATP channel subunits protected natively KATP channel-deficient cells provides direct evidence that the cardiac KATP channel protein complex harbors intrinsic cytoprotective properties. These findings validate the concept that targeting cardiac KATP channels should be considered a valuable approach to protect the myocardium against injury. (Circulation. 1998;98:1548-1555.)

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