Evidence for a New Pathophysiological Mechanism for Coronary Artery Disease Regression: Hepatic Lipase-Mediated Changes in LDL Density

    loading  Checking for direct PDF access through Ovid



Small, dense LDL particles are associated with coronary artery disease (CAD) and predict angiographic changes in response to lipid-lowering therapy. Intensive lipid-lowering therapy in the Familial Atherosclerosis Treatment Study (FATS) resulted in significant improvement in CAD. This study examines the relationship among LDL density, hepatic lipase (HL), and CAD progression, identifying a new biological mechanism for the favorable effects of lipid-altering therapy.


These studies support the hypothesis that therapy-associated changes in HL alter LDL density, which favorably influences CAD progression. This is a new and potentially clinically relevant mechanism linking lipid-altering therapy to CAD improvement. (Circulation. 1999;99:1959-1964.)

Related Topics

    loading  Loading Related Articles