Expression of Cell Adhesion Molecules in Dilated Cardiomyopathy: Evidence for Endothelial Activation in Inflammatory Cardiomyopathy

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Abstract

Background

Dilated cardiomyopathy (DCM) is pathogenically linked to inflammatory cardiomyopathy (InfCM), which is characterized by intramyocardial infiltration. The transendothelial migration of immunocompetent cells is mediated by cell adhesion molecules (CAMs).

Conclusions

Inflammatory endothelial activation is present in 67% of DCM patients. Because CAM expression correlates with the immunohistological diagnosis of InfCM and counterreceptor-bearing intramyocardial infiltrates, evaluation of endothelial CAMs might be of diagnostic significance in InfCM. (Circulation. 1999;99:2124-2131.)

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