Abstract 108: New Assessment Of Comprehensive Coagulation Function Using Clot Waveform Analysis In Patients With Kawasaki Disease In The Acute Phase

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Abstract

Background: Hypercoagulability for Kawasaki disease (KD) in the acute phase is known, through many reports based on the change of the individual coagulation factor. Little information on the assessment of comprehensive coagulation function of this disease is described, however. A recent developed clot waveform analysis (CWA), defines changes in light transmittance that occur during the process of clot formation, can assess comprehensive coagulation function qualitatively and quantitatively by measuring the parameters. In this study, we have investigated the clotting dynamics of acute-phase KD by CWA. Method: The subjects were 43 patients of KD with treatment of intravenous γ-globulin (IVIG), at onset ranged from 3 months to 5 years old (median 1.8 years old). Normal pooled plasma (NP) was prepared from 20 healthy individuals. Blood samples were collected at three points of time; before the IVIG administration (Pre), after 1 week of IVIG (1W), and after 1 month of IVIG (1M). Cases with anticoagulant medication were excluded. CWA was performed using MDA-II™, and parameters, clotting time (CT), maximum coagulation velocity (dT/dt,

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