Background and Objectives: Kawasaki disease is the leading cause of acquired heart disease among children in most industrialized countries.However, only few descriptive studies discussed the pros and cons of early immunoglobulin therapy. The aim of this study isto see the effect of early immunoglobulin therapy on Kawasaki disease outcomes.
Methods: This study enrolled patients who received immunoglobulin therapy for the first time. Basic data was analyzed for descriptive epidemiology. Clinical risk factors of acute coronary aneurysm, chronic coronary aneurysm and recurrence rate were analyzed.
Results: Totally 5235 patients of first attack of Kawasaki disease were enrolled. Among them, 1156 children were classified as early immunoglobulin therapy. The odds ratio for acute aneurysm and needing long-term anti-coagulant therapy were 0.94 (95% CI, 0.77~1.16) and 1.01 (95% CI, 0.77~1.32) respectively. The recurrence rate was higher for early immunoglobulin therapy group. The adjusted odds ratio was 1.86 (95% CI, 1.07~3.23).
Conclusions: Early immunoglobulin therapy might not benefit the coronary outcomes for children of Kawasaki disease. On the contrary, it might be associated with higher recurrence rate.