Background: Noninvasive recognition of abnormalities of depolarization (DE) and repolarization (RE) in patients with coronary artery disease is difficult.
Purpose: Our aim was to identify abnormalities of DE and RE in patients with coronary artery lesions (CAL) due to Kawasaki disease (KD) using magnetocardiography (MCG).
Methods: We evaluated sixty one pts (48 males and 13 females) with CAL due to KD, The age at MCG ranged from 11 months to 38 years (median 15 years). Eleven pts had had previous myocardial infarction (MI), and 22 pts had had at least an occlusion of a major coronary artery branch. MCG was performed at rest with a multichannel superconducting quantum interference device system. The integral value was computed for each channel and isointegral maps were constructed during DE and RE. We analyzed abnormalities of DE and RE depending on occlusion of coronary arteries (OC) or a history of MI. Univariate analysis was performed on respective factors for DE and RE.
Results: In the MI group, the number of abnormal DE and RE, abnormal DE and abnormal RE were 3 , 1 and 3, respectively. In OC group, the number of abnormalities of DE and RE was 2, and abnormality of RE was 9. In the non-OC group, the number of abnormal DE and RE was 2, and abnormal RE was 5. The factor of MI was significantly related on abnormal DE and abnormal RE (p<0.05). On the other hand, the factor of OC was significantly related to abnormality of RE (p<0.05).
Conclusion: Although symptomatic coronary occlusion affects both DE and RE, occlusion of coronary artery only affects RE. MCG is useful to detect changes in DE and RE.