Abstract 77: Association of Sodium and Coronary Arteriopathy in Acute Phase of Kawasaki Disease

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Abstract

Background: Kawasaki disease(KD) is an immune related multisystemic inflammatory vasculitis in children, especially ensues coronary artery lesions. Several cardiovascular diseases are known to be correlated with sodium level. In this study, we examined the association between serum sodium levels and the severity of coronary artery lesion in acute phase of Kawasaki disease.

Objective: The purpose of this study was to determine the association of serum sodium level for predicting cardiac events in Kawasaki disease (KD) patients especially in coronary artery lesions (CALs).

Methods: We conducted a retrospective review of the medical records of 158 Kawasaki disease patients from June 2013 to August 2014. We devided the subjects into two groups regarding to the serum sodium level. Various laboratory tests and echocardiographic data were analyzed. Student t-tests were carried out to analyze the significance of the difference in each group.

Results: ESR, CRP, BNP, and liver enzymes were significantly greater in lower sodium group. Echocardiographic diastolic marker of mitral E and E/E’ measurement were statistically different. Coronary arterial changes were significant in lower sodium group as well.

Conclusions: The lower sodium group demonstrated significant increase of various inflammatory markers and coronary arterial lesions. The sodium level might be associated with the severity of coronary vessel and cardiac inflammation in acute phase of Kawasaki disease.

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