Sleep duration and circadian preference (morningness/eveningness preference or “chronotype”) have separately been associated with cardiovascular risk behaviors including tobacco use and physical inactivity. Interactive effects are plausible, resulting from combinations of sleep homeostatic and circadian influences. But these have not been explored previously. To address this, associations between combinations of sleep duration (short [≤6h], adequate [7-8h], long [>9h]) and chronotype (morning, intermediate, evening) were examined relative to tobacco use, physical inactivity, sedentary behavior, and overweight, in a cross-sectional sample of 439,933 adults enrolled in the United Kingdom Biobank project. The study sample was 56% female, 95% white, and the mean age was 56.5 (SD=8.1) years. Most participants engaged in 1 (39%) or 2 (35%) risk behaviors; 10% engaged in 3, 1% engaged in 4 while 15% engaged in 0. Compared to morning types with adequate sleep (referent group), evening types with long sleep had 1.98-fold odds of not meeting physical activity recommendations, 1.47-fold odds of being overweight, and 2.19-fold odds of high sedentary behavior. Evening types with short sleep had 3.36-fold odds of being smokers as compared to morning types with adequate sleep. All models were adjusted for age, sex, race, college attendance and shift work. These data suggest an interactive relationship between sleep duration and chronotype, such that evening types who do not get adequate sleep may be most at risk for poor heart health behaviors. Further work is needed to determine the effects of chronotherapeutic interventions (i.e., shifting evening toward morning preference) on heart health behaviors.