Abstract 17211: Left Atrial Strain Adds Prognostic Value to Left Ventricular Global Longitudinal Strain in Heart Failure Patients Treated by Cardiac Resynchronization Therapy With Intermediate Electrocardiographic Criteria

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Introduction: Response to cardiac resynchronization therapy (CRT) has been difficult to predict in heart failure (HF) patients with QRS width 120-149ms or non-left ventricular brunch block (LBBB), defined as intermediate ECG criteria. Although global longitudinal strain (GLS) has been shown to be predictive of response, the influence of left atrial (LA) speckle tracking strain as a novel marker in CRT-eligible patients is unknown.

Hypothesis: We hypothesized that LA deformation by speckle-tracking strain is of additive prognostic value to patients undergoing CRT implantation.

Methods and Results: We selected 120 HF patients with QRS 120-149ms or non-LBBB and ejection fraction

Conclusion: Baseline LA strain was of additive prognostic value to GLS for clinical outcomes in CRT patients with intermediate ECG criteria (QRS 120-149ms or non-LBBB). LA strain combined with GLS has promise for clinical prognostic utility in HF patients with intermediate ECG criteria undergoing CRT.

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