Abstract 18868: Ethnic and Gender Differences in the Occurrence and Outcomes in Patients With Diabetes

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Introduction: Approximately 25% of patients who undergo percutaneous coronary intervention (PCI) have diabetes which nearly doubles the mortality risk. The prevalence of diabetes varies among different ethnic groups and between the sexes. PLATINUM Diversity assessed 1-year outcomes after PCI in women and minority groups.

Hypothesis: The impact of diabetes may differ according to ethnicity or gender. In the present analysis, we investigate the prevalence and impact of diabetes in women and minorities undergoing PCI compared with white men.

Methods: PLATINUM Diversity (N=1501) was a single-arm enriched cohort study enrolling only women and minorities and included pre-specified patient-level pooling with the PE Plus PAS (N=2681). For the current analysis, we classified patients into 8 subgroups: patients with and without medically-treated diabetes (those treated with an oral or injectable agent including insulin) who were white men, white women, minority men or minority women.

Results: The prevalence of medically-treated diabetes was significantly higher in minority women (228/427, 53.4%), minority men (252/632, 39.9%), and white women (473/1417, 33.3%) undergoing PCI, compared to white men (501/1635, 30.6%; all p<0.05). Unadjusted cardiac event rates in the subgroups with and without diabetes are shown in the table. The rate of death/MI in minority patients with diabetes was significantly higher than in white men; MI was significantly increased in minority women with diabetes. For the presentation, the interaction between ethnicity, gender, and diabetes will be investigated. Additionally, insulin-treated patients will be evaluated and the impact of social determinants of health will be investigated.div>

Conclusions: In PLATINUM Diversity, diabetes was more prevalent in women and minority patients than in white men. The risk of cardiac events in diabetics was higher than in non-diabetics; this difference was greatest in minority women.

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