Introduction: Left ventricular hypertrophy (LVH) is a significant risk factor of sudden cardiac death (SCD). We evaluated the association between LVH and SCD. The prevalence of LVH in SCD was also compared between two study populations in Bangkok, Thailand, and Wake County, NC, USA.
Methods: Medical examiner reports from Department of Forensic Pathology, Ramathibodi Hospital, Bangkok, from 2010 to 2014, were reviewed. Out of hospital sudden unexpected deaths (OHSUD) between age of 18 to 65 year-old were identified and divided into 2 groups; SCD and non-SCD. SCD was defined as an unexpected death due to a cardiac cause within 24 hours of being seen well. LVH was identified from autopsy reports, previous electrocardiogram, or previous echocardiogram. Conventional risk factors including LVH were compared to the Sudden Unexpected Death in North Carolina (SUDDEN study) from 2013 to 2015 by the same definition and selection criteria.
Results: Among 1950 medical examiner reports in Bangkok, 325 OHSUD were identified (83.4% males; mean age 47.8 ± 9.9). SCD is the leading cause of OHSUD (57.8%). Interestingly, LVH is statistically prominent in SCD when compared to non-SCD in Bangkok (46.3% VS. 23.4%, p<0.001) as well as in Wake County (50.0% VS. 38.0% , p=0.025). Comparison of conventional risk factors between two populations is shown in Table 1. The prevalence of LVH in SCD is not significantly different among Bangkok and Wake County (46.3 VS. 50.0%, p=0.49).
Conclusion: Our study confirmed high prevalence of LVH in SCD as we as their association both in Bangkok and Wake County population. Preventive intervention targeting high-risk groups with LVH could be an effective prevention strategy for SCD.