Introduction: Since the introduction of the new Lung Allocation Score (LAS), idiopathic pulmonary fibrosis (IPF) has become the most common indication for either single or double lung transplantation (LTx).
Hypothesis: We hypothesized that the survival outcome of IPF patients would be similar following single (SLT) or double lung transplantation (DLT). quaternary hospital.
Methods: 247 IPF patients that underwent either single or double LTx at our center from 2012 to 2016 were reviewed retrospectively. Demographics, recipients’ age and height, donor age and height, LAS, length of stay (LOS), survival days, death, types of induction, and surgical procedures were compared between SLT vs DLT in IPF patients for significance. Acturial survival was assessed by Kaplan-Meier curve and compared by log-rank test. Data were expressed as mean ± standard deviation and p-value less than 0.05 was considered as statistically significant (Stata 14).
Results: 67% had an etiology of IPF (n=165), 85 and 80 had SLT and DLT (p=0.99). There were no significant differences between SLT vs DLT in recipient gender (75%vs. 66% male; p=0.2), BMI (p=0.71), donor age (p=0.59), gender (p=0.11), and height (p=0.99), induction type (p=0.59), and concomitant surgery (p=0.18). Recipient age was higher in SLT (67 vs 62 years; p=0.03), LAS in DLT (68 vs. 51; p=0.005), median LOS was higher in DLT (22 vs. 15 days; p=0.005), higher antero-axillary in SLT (59% vs 41%; p<0.05), higher Clamshell in DLT (28% vs. 0%; p<0.001). Systolic and diastolic pulmonary artery pressure were higher in DLT (47±2 vs 38±1 and 19±1 vs. 14±1 mmHg; p<0.001). K-M curve showed no survival difference in SLT vs DLT in all IPF patients (p=0.59).
Conclusions: Single center results showed higher LAS, PA pressure, and LOS in DLT IPF patients. Short and mid-term survival was not different with regard to IPF when patients underwent either single or double lung transplantation. Long-term follow up of these patients are needed.