Abstract 20002: Genetic Determinants of Heart Rate Recovery

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Abstract

Background: Heart rate recovery (HRR) after exercise is an important predictor of sudden cardiac death. The mechanistic basis underlying differences in heart rate recovery remains to be elucidated. We report the first large genome wide analysis of HRR. Heart rate recovery (HRR) after exercise is an important predictor of sudden cardiac death. The mechanistic basis underlying differences in heart rate recovery remains to be elucidated. We report the first large genome wide analysis of HRR.

Objective: The aim of this study was to identify common genetic variants associated with HRR.

Method and Results: In UK Biobank, 18,352 individuals with genetic data completed a 7 minute exercise test. HRR was defined as the difference between peak exercise rate and the heart rate at 50 seconds. Statistical analyses were adjusted for age, sex, BMI, exercise duration, maximum workload, genotyping chip and 15 PCAs. The mean duration of exercise was 352±39 seconds, the mean recovery phase 52±1 seconds and the mean HRR 32.5±10.6 beats per minute. BOLT-REML analyses estimated the SNP-heritability of HRR to be 0.278±0.03, higher than other available heart rate variables. Genome wide association analysis of HRR identified 2 genome wide significant loci: rs7971226 in SYT10 (P=6.5E-22) and rs58394792 in CHRM2 (P=1.9E-8), explaining a total of 0.64% of the phenotypic variance.

Conclusion: Variants in CHRM2 and SYT10 were genome wide significant for HRR. Future analyses will include a larger sample size, assessment of functional genomic variation, and also genetic correlations among other heart rate variables and clinical data to provide additional insights into the (patho-) physiology of HRR.

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