Introduction: Physical activity is associated with reduced risk of developing myocardial infarction (MI). It has not been established whether a history of physical activity is also associated with short-term MI case fatality.
Hypothesis: Leisure-time physical activity (LTPA) reduces rates of fatal MI and 28-day MI case fatality.
Methods: Participants from the Copenhagen General Population Study (CGPS), a prospective population-based study, included in 2003-2014 with self-reported LTPA in three categories measured at baseline were followed until 2014 through national registries. The study population consisted of participants with a first time MI and outcomes were defined as: 1. Fatal MI (defined as date of death same as date of MI including any death registered with MI as cause) and 2. 28-day fatality. Through univariate and multivariate logistic regression analysis the association between baseline LTPA and outcomes adjusted for potential confounders (age, gender and CVD risk factors) was assessed.
Results: A total of 1517 of participants with first time MI were included in the study population. Median time from baseline assessment of LTPA to MI was 3.58 years (1.83-5.81). 117 MIs (7.7%) were fatal and further 79 (5.6%) died within 28 days. LTPA was associated with lower risk of fatal MI with OR of 0.40 (0.22-0.73) for light and 0.41 (0.22-0.76) for moderate/high LTPA after multivariable adjustment with sedentary level as reference. Age, alcohol-intake, education and smoking were identified as predictors for fatal MI. We found no associations between baseline LTPA and further 28-day case fatality.
Conclusions: Adjusted for multiple possible confounders LTPA was identified as a predictor for reduced rates of fatal MI. There was no dose-dependent association. LTPA was not associated with 28-day case fatality.