Background: Although patients with collagen disease have an increased risk of cardiovascular disease because of chronic inflammation, their prognosis and prognostic factors are fully unknown after percutaneous coronary intervention (PCI). However, the neutrophil-to-lymphocyte raito (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) and their possible value as prognostic marker have not been evaluated.
Methods: From April 2007 to October 2014, 627 consecutive patients who underwent PCI were enrolled. We compared long-term outcomes of 33 patients with collagen disease to 543 patients with non-collagen disease. Primary endpoint was major adverse cardiac events (MACE) which was defined as cardiovascular death, myocardial infarction (MI), and target lesion revascularization (TLR). Otherwise, optimal cut-off value of NLR, LMR and PLR were compared.
Results: Incidence of MACE was significantly more observed in collagen disease than in non-collagen disease (24.2%vs.10.1%, p=0.002). Kaplan-Meier analysis demonstrated that there were significant differences in MACE (p=0.036). In multivariable analysis, collagen disease was independent predictor for MACE after adjusting confound factors (HR 3.29, 95% CI:1.30-8.35, p=0.01). In patients with collagen disease, Multivariable analysis demonstrated that LMR values < 2.0 was independent predictor for MACE (HR 15.68, 95% CI: 1.20-205.29, p=0.04) .
Conclusion: Patients with collagen disease had poor long-term cardiovascular outcomes and a lower value of LMR is independently associated with incidence of MACE after receiving PCI.