Abstract 21345: Diastolic Blood Pressure is the Predictors of Left Ventricular Myocardial Relaxation in Healthy Postmenopausal Women

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Introduction: Previous studies that indicate metabolic syndrome (MetS) might be at risk for left ventricular (LV) diastolic dysfunction. However, little is known about which metabolic factors contribute to the development of LV dysfunction in postmenopausal women without obesity or overweight, diabetes mellitus, and/or cardiovascular disease.

Methods: Participants without diabetes mellitus, systolic dysfunction, or other heart diseases underwent a thorough physical examination including tissue Doppler echocardiography. A peak early mitral annular velocity (e′) of <5.0 was designated as indicating abnormal LV myocardial relaxation (LVMR). We performed single and multiple logistic regression analyses of e′ and cardiovascular risk factors, including MetS factors and indicators of major organ dysfunction. Normal-weight subjects (body mass index <25 kg/m2) were also analyzed.

Results: A total of 269 postmenopausal women (mean age, 70 ± 7 years) participated, of which 29 (10.8%) had MetS and 67 (23.8%) had abnormal LVMR. Multiple logistic regression analysis revealed high diastolic blood pressure: DBP (odds ratio [OR] 5.3, 95% confidential interval [CI] 1.89 - 15.0, P < 0.01), abnormal waist circumference (OR 2.4, CI 1.15 - 5.01, P < 0.01) and age (OR 1.1, CI 1.05 - 1.16, P < 0.01) to be predictors of abnormal LVMR. In normal-weight subjects (n = 232), high DBP (OR 5.1, CI 1.65 - 15.89, P < 0.01), and aging (OR 1.1, CI 1.06 - 1.17, P < 0.01) were predictors of abnormal LVMR.

Conclusions: In postmenopausal women, only diastolic blood pressure was the independent risk factors for abnormal LVMR in both normal-weight and over-weight individuals, and therefore might be useful for predicting diastolic heart failure during routine physical checkups.

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