Abstract P203: Serum Metabolites Associate With Blood Pressure Phenotypes in the Bogalusa Heart Study

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We conducted a metabolome-wide association study to identify blood pressure (BP)-related metabolites among 825 white and 436 African-American Bogalusa Heart Study (BHS) participants. After quality control, 1,202 metabolites were tested for association with systolic BP (SBP), diastolic BP (DBP), and hypertension in race-stratified analyses. Multiple regressions were used to adjust for age, sex, education, cigarette smoking, alcohol drinking, physical activity, and body mass index. Weighted correlation network analysis was utilized to identify modules of co-abundant metabolites that associated with covariable adjusted BP phenotypes. After Bonferroni corrections, 16 metabolites from amino acid, cofactor and vitamin, lipid, carbohydrate, and peptide pathways in whites and one from the carbohydrate pathway in African-Americans significantly associated with BP phenotypes. Two novel and one previously reported metabolite consistently associated with hypertension across race groups (Table). Among whites, modules consisting primarily of lipid metabolites including phosphatidylcholines, phosphatidylinositol and lysophospholipids (P=1.0х10-3 and 6.0х10-4 for SBP and DBP, respectively), monoacylglycerols and lysophospholipids (P=3.0х10-4 and 7.0х10-5 for SBP and DBP, respectively), and phosphatidylethanolamines, mono- and diacylglycerols, and lysophospholipids (P=4.0х10-4 and 4.9х10-4 for SBP and hypertension, respectively) were identified. In addition, modules consisting primarily of amino acids and peptides such as gamma-glutamyl amino acid metabolites and those involved in leucine, isoleucine and valine metabolism were significant in both African-Americans (P=2.0х10-3 and 1.5х10-3 for DBP and hypertension, respectively) and whites (P=7.1х10-4 for hypertension). In aggregate, the current analysis identified novel metabolites and metabolite modules involved in BP regulation. These data add to the accumulating evidence that serum metabolites may play an important role in BP.

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