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A 50-year-old female patient with an 8-year history of a mass in the right breast which has undergone rapid progressive growth, involving the entire breast, over the past 7 months, diagnosed as a phyllodes tumor. Simple right mastectomy with axillary lymph node dissection and pectoralis major fascia resection were performed under general anesthesia. Ultrasound-guided erector spinae plane block was performed for postoperative analgesia, with excellent response up to 18 hours following the procedure, and no need for additional opioids. There were no adverse effects or complications associated with the block.Ultrasound-guided erector spinae block is a fast and safe procedure that may be used as a valuable adjunct to ensure postoperative analgesia in radical mastectomy cases, which pose a challenge in terms of pain control. Moreover, it offers an advantage in terms of reduced opioid requirement in these patients.