Growth inhibition effect of DL-lysine acetylalicylate on sw480 colon carcinoma cells

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Abstract

Objective

To investigate the effect of DL-lysine acetylsalicylate on proliferation of colon carcinoma cells line sw480.

Methods

After treatment of DL-lysine acetylsalicylate, the study was performed by observing sw480 colorectal cancer cells with phase contrast microscope, making growth curve, and examining the inhibition rate of sw480 cells with MTT assay.

Results

The morphology of sw480 cells showed characteristics of apoptosis, the cell growth curve showed inhibited proliferation of sw480 cells when treated with DL-lysine acetylsalicylate (P<0.05). The rate of inhibition was upward when the drug concentration increased.

Conclusion

DL-lysine acetylsalicylate for injection can inhibit the growth of sw480 colorectal cancer cells obviously in a dose dependent manner.

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