Prognostic value of P-gp and p27 in patients with esophageal squamous cell carcinoma

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Abstract

Objective

To evaluate the prognostic value of P-gp and p27 expression in patients with esophageal squamous cell carcinoma (ESC).

Methods

The expressions of P-gp and p27 were detected by immunohistochemistry in 104 cases of ESC, and the clinicopathological characteristics were analyzed as well.

Results

The positive rate of P-gp expression in 104 cases of ESCs was 32.7%. The positive rate of P-gp expression in the group that survived over 3 years (17.5%) was significantly lower than that in the group died within 3 years (53.3%) (x2=14.227, P<0.001). The positive rate of p27 expression in 104 cases of ESCs was 67.3%. The positive rate of p27 expression in the group that survived over 3 years (75.8%) was significantly higher than that in the group died within 3 years (56.5%) (x2=4.361, P<0.05). The patients with poorer differentiation whole wall invasion, lymph node metastasis and more advanced TNM stage had a shorter survival than did those with better differentiation, more superficial invasion, no lymph node involvement and earlier TNM stage; and it was statistically significant (P<0.05). However, tumor size, macropathologic type, age and gender had no prognostic impact on ESC patients (P>0.05).

Conclusion

P-gp and p27 expression levels had a clinical prognostic significance in ESC. It could provide a reference basis for selecting the chemotherapy projection. The tumor differentiation degree, depth of invasion, lymph node involvement and TNM stages all were correlated to ESC patients' survival.

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