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Atypical hemolytic uremic syndrome (aHUS), a condition found in adult and pediatric populations, can be idiopathic or acquired as a result of major systemic changes. aHUS presents with a wide array of symptoms that can be attributed to other less dangerous conditions. Because of its complex nature and rare occurrence, it is typically diagnosed in later stages and with multiple organ involvement.This article provides an overview of aHUS and available interventions.Current aHUS literature was reviewed, and implications for nursing care were identified.Early diagnosis is crucial to achieve positive patient outcomes. The difference in pathology among the different thrombotic microangiopathies and their appropriate management must be understood. Although aHUS requires a multidisciplinary approach, nurses play a crucial role in assessing disease progression and identifying possible complications.