Fixed Combination Antiemetic

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A literature review on prevention of chemotherapy-induced nausea and vomiting using netupitant/palonosetron


Prevention of chemotherapy-induced nausea and vomiting (CINV) can be improved with guideline-consistent use of antiemetics. However, adherence to antiemetic guidelines remains often insufficient. Therefore, new strategies that improve adherence are needed.


To review the latest antiemetic guideline recommendations and provide an update on the use of NEPA, a fixed combination antiemetic composed of the neurokinin-1 receptor antagonist (RA) netupitant and the 5-hydroxytryptamine-3 RA palonosetron (Akynzeo®).


Analysis of the literature was performed, including guidelines, published literature, congress data on NEPA, and relevant articles on CINV.


Increased knowledge about CINV treatment recommendations and new antiemetic agents allow nurses to promote individualized antiemetic prophylaxis and maximize supportive patient care. Nurses are in a unique position to promote guideline-consistent antiemetic prophylaxis and are central in the education of patients and caregivers.

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