Fixed Combination Antiemetic

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Abstract

A literature review on prevention of chemotherapy-induced nausea and vomiting using netupitant/palonosetron

BACKGROUND:

Prevention of chemotherapy-induced nausea and vomiting (CINV) can be improved with guideline-consistent use of antiemetics. However, adherence to antiemetic guidelines remains often insufficient. Therefore, new strategies that improve adherence are needed.

OBJECTIVES:

To review the latest antiemetic guideline recommendations and provide an update on the use of NEPA, a fixed combination antiemetic composed of the neurokinin-1 receptor antagonist (RA) netupitant and the 5-hydroxytryptamine-3 RA palonosetron (Akynzeo®).

METHODS:

Analysis of the literature was performed, including guidelines, published literature, congress data on NEPA, and relevant articles on CINV.

FINDINGS:

Increased knowledge about CINV treatment recommendations and new antiemetic agents allow nurses to promote individualized antiemetic prophylaxis and maximize supportive patient care. Nurses are in a unique position to promote guideline-consistent antiemetic prophylaxis and are central in the education of patients and caregivers.

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