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Quality of life for persons living with multiple sclerosis (MS) is significantly lower than population norms. Fatigue, both physical and cognitive, is one of the most prevalent and debilitating symptoms of MS that decrease quality of life. Cognitive fatigue presents similarly to sensory overresponsiveness, but the connection has not been explored.This study aims to describe how sensory-processing preferences and cognitive fatigue relate to variances in quality of life for people with MS.A cross-sectional design was used with 30 people living with MS to complete the Adolescent/Adult Sensory Profile (AASP), Modified Fatigue Impact Scale, and RAND-36. Spearman’s coefficient measured nonparametric correlations between variables.People with MS who have high scores in low registration, sensory sensitivity, and sensation avoidant quadrants of the AASP also have higher levels of cognitive fatigue and poorer quality of life. Those with high scores in sensory seeking experience greater quality of life and less cognitive fatigue.The findings shape clinical practice by supporting the assessment of sensory processing alongside fatigue, offering individualized intervention planning to shape fatigue management, and fostering hope and quality of life for persons living with MS.