Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049)

    loading  Checking for direct PDF access through Ovid

Abstract

Objective

To study the association between serum anti-Müllerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5·2–12·1μg/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a GnRH antagonist protocol.

Design

Secondary analysis of a randomized controlled trial with stratified randomization according to AMH (lower stratum: 5·0–14·9 pmol/l; higher stratum: 15·0–44·9 pmol/l).

Patients

Infertile women of good prognosis (n = 265).

Measurements

Follicular development and endocrine parameters during controlled ovarian stimulation (COS) with rhFSH.

Results

Serum FSH levels increased with increasing rhFSH doses and steady-state levels for each dose were similar in both AMH strata. In the whole study population, significant (P < 0·001) positive dose responses were observed for the number of follicles ≥12 mm, and serum levels of oestradiol, inhibin B, inhibin A and progesterone at end of stimulation. In comparison with the higher AMH stratum, patients in the lower AMH stratum had significantly different slopes of the dose–response curves for these hormones, and no clear dose-related increase was observed for the number of follicles in these patients.

Conclusions

Dose–response relationships between rhFSH and follicular development and endocrine parameters are significantly different for IVF/ICSI patients with lower and higher serum AMH levels at start of COS.

Related Topics

    loading  Loading Related Articles