Loss of dynamic histone regulation underlies mental retardation

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The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases Iwase et al. (2007) Cell 128: 1077–1088

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation Tahiliani et al. (2007) Nature 447: 601–606

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