Genetic Diversity of Invasive Strains ofHaemophilus influenzaeType b before and after Introduction of the Conjugate Vaccine in Italy

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Abstract

We determined the genotypes of 95 invasive Haemophilus influenzae type b (Hib) strains collected before and after introduction of widespread Hib vaccination in Italy. No substantial change in genetic diversity was highlighted by pulsed-field gel electrophoresis. However, an upward temporal trend in proportion of strains possessing multiple copies of the capsulation b locus was detected (P = .03).

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