Human infection due toBacillus pumilusis exceptional. We report 3 cases of cutaneous infection caused byB. pumilusthat occurred in 3 shepherds, 2 of whom were members of the same family. The lesions appeared to have a morphology similar to that of cutaneous anthrax lesions. Two patients were cured after treatment with amoxicillin-clavulanate, and the third patient was cured after prolonged treatment with ciprofloxacin. To our knowledge, primary cutaneous infection due toB. pumilushas not been reported.B. pumilusshould be considered in patients who develop lesions suggestive of cutaneous anthrax.