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In a Chinese study of hypertensive adults without history of stroke or myocardial infarction, the combined use of enalapril and folic acid, compared with enalapril alone, significantly reduced the risk of first stroke.Huo Y, et al. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China. The CSPPT randomized clinical trial. JAMA 2015;313:1325-1335.