1Laboratory of Clinical Chemistry, National Institute of Nutrition, Bab Saadoun, Tunis, Tunisia2Department of Pathology, Hartford Hospital, Hartford, CT, USA3Department of Chemistry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK4Instrumentation Laboratory, Lexington, MA, USA5Laboratory of Clinical Chemistry, Herlev Hospital, Herlev, Denmark6Clinical Laboratory Program, Wadsworth Center, NY State Department of Health, Albany, NY, USA7Department of Chemistry, University of Durham, Durham, UK8Klinische Chemie, Medizinische Hochschule, Hannover, Germany9Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan10Department of Clinical Chemistry, University of Linkoping, Sweden11Center ProSens, Åbo Akademi University, Abo-Turku, Finland12Eurotrol bv, Ede, Netherlands13Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany14Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland15Department of Pathology, John Sealy Hospital, Galveston, TX, USA16Roche Diagnostics GmbH, Graz, Austria17ARC Consulting, 14 Learoyd Street, MT Lawley, Australia
Checking for direct PDF access through Ovid
The proposed recommendation for measuring and reporting chloride in undiluted plasma† or blood by ion-selective electrodes (ISEs) will provide results that are identical to chloride concentrations measured by coulometry for standardized normal plasma or blood samples. It is applicable to all current ISEs dedicated to chloride measurement in undiluted samples that meet the requirements. However, in samples with reduced water concentration, results by coulometry are lower than by ion-selective electrode due to volume displacement. The quantity measured by this standardized ISE procedure is called the ionized chloride concentration. It may be clinically more relevant than the chloride concentration as determined by coulometry, photometry or by ISE after dilution of the sample.