Increased glycation of hemoglobin and plasma proteins in normotensive, non-diabetic obese Indian subjects: putative role of lipid peroxides


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Abstract

BackgroundGlycation and lipid peroxidation are spontaneous reactions believed to contribute to the pathogenesis of many clinical disorders. The purpose of the present study was to evaluate the levels of lipid peroxides and glycated proteins in normotensive, non-diabetic obese Indian subjects and to assess possible associations between them.MethodsA total of 28 obese male subjects and 20 non-obese subjects were included in the present study. Whole blood glycated hemoglobin, plasma lip-id peroxides and fructosamine levels were estimated in both groups.ResultsLipid peroxides, glycated hemoglobin and fructosamine levels were significantly higher in obese subjects in comparison with non-obese subjects. We also found a significant association between malon-dialdehyde and body mass index (r=0.424, p=0.025). Partial correlation analysis revealed that malondial-dehyde was significantly correlated with glycated hemoglobin (r=0.590, p=0.01) and fructosamine (r=0.442, p=0.021) after controlling for glucose.ConclusionsIncreased glycation of proteins was found in normotensive, non-diabetic obese Indian subjects. These data also support the premise that lip-id peroxides per se play a role in the glycation of hemoglobin and plasma proteins.

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