Testosterone is an independent determinant of bone mineral density in men with type 2 diabetes mellitus


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Abstract

BackgroundAlthough many reports have elucidated pathophysiological characteristics of abnormal bone metabolism in patients with type 2 diabetes mellitus (DT2), determinants of bone mineral density (BMD) in patients with DT2 are still controversial.MethodsWe examined 168 Belarussian men 45–60 years of age. Plasma total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, triglycerides, hemoglobin A1c (HbA1c), immunoreactive insulin, and C-reactive protein concentrations were assessed. BMD was measured using dual energy X-ray densitometry of the lumbar spine (L1–L4). Total testosterone (TT) and sex hormone-binding globulin were measured, and free testosterone (FT) was calculated.ResultsUsing univariate linear regression analysis, BMD of the lumbar spine was significantly correlated with FT (r = 0.32, p < 0.01) and TT (r = 0.36, p < 0.01). Using multiple linear regression analysis adjusted for confounding factors, BMD was significantly correlated with TT (β = 0.23, p < 0.001) and TC (β = −0.029, p = 0.005). Age (β = 0.005, p = 0.071), body mass index (β = 0.005, p = 0.053), HbA1c (β = −0.002, p = 0.72) and duration of diabetes (β = 0.001, p = 0.62) were not significantly correlated with BMD.ConclusionsOur data indicate that androgens are independent determinants of BMD in male patients with DT2.

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