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The aim of this study was to evaluate the reproducibility of bone mineral density (BMD) measurements of the periprosthetic bone in patients with hemispherical acetabular cups in cementless total hip arthroplasty (THA). Thirty patients were treated for primary osteoarthrosis with cementless THA. Dual-energy X-ray absorptiometry (DXA) scanning was performed with a pencil-beam bone densitometer (Norland XR-36). Accuracy and reproducibility was determined by double measurements of BMD in four regions of interest (ROI). The influence of patient postures including various pelvic inclination angles was evaluated as well. Pitman test for a combined netROI revealed a standard deviation ratio of 3.2 for the anterio–posterior scans related to the lateral position. The Wilkinson ROIs showed a high intraobserver agreement. With pelvic tilt increasing until 20°, the precision of DXA scanning decreased. In conclusion, reproducibility of DXA scanning was high. This study demonstrated that the patients can be scanned in the supine position, and BMD measurement of the periacetabular bone can be performed using the Wilkinson model with four rectangular ROIs.