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An 11-year-old girl with de novo r(15) Ip12q26.3) with a clinical diagnosis of Silver-Russell syndrome (SRS) is presented. She had prenatal and postnatal growth deficiency with a severe short stature, peculiar facies characterized by a triangular face, a pinched nose with anteverted nostrils and down-turned corners of the mouth, bilateral clinodactyly of the fifth fingers, café-au-lait nevi, mental retardation, and a high level of seurm follicular stimulating hormone. Southern blot analysis and chromosome fluorescence in situ hybridization revealed a detection of the insulin-like growth factor 1 receptor gene (IGFIR) in the patient, the result indicating that IFFIR is assigned to 15q26.3. The detected segment in our patient and comparisons with those of other reported cases of 15q-suggests that one of the putative SS LOCI is at 15q26.3.