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A patient-lead fault interruptor (PLFI) is presented that behaves as a current-controlled device. It is normally “closed,” and “opens” if a fixed threshold current level is exceeded. It is self-protecting in that it opens up before it can exceed its own current rating. Once the trip point of the current-controlled device is exceeded, the voltage-current relationship shows a negative slope during the transition to the open circuit state. The trip time under fault condition is of the order of a few microseconds. Applications of PLFIs are described in this article.