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Technology Assessment (TA) is a relatively new concept with a heterogeneous “community” of practitioners and advocates. Consequently, there is much confusion about this new analytic strategy. Many people, for example, confuse TA with other technology studies such as engineering feasibility, market research, clinical trials, cost-benefit, environmental impact, technology forecasting, or technology transfer. This article, which draws most of its examples from the field of health, attempts to allay the confusion by showing how TA differs significantly from other technology studies and by describing both the opportunities and the obstacles involved in conducting comprehensive assessments.