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Coupling between different regions of the brain plays an important role in many functions of the brain. Dynamical changes occurring in coupling strengths between brain regions can result in synchronous activity within neuronal populations, which in turn render epileptic seizures happen. Knowing this fact can help us to develop new prediction systems with better performance. This seizure prediction study takes coupling strength into account to detect preictal changes several minutes before seizures. Simulation results indicate that preictal changes begin 20 to 25 minutes before upcoming seizures.