Foreword
Preface
Summary of the conclusions
Histamine and the antiallergic antihistamines: a history of their discoveries
Discussion: The history of histamine and antihistamines
Why are non-sedating antihistamines non-sedating?
Molecular properties and signalling pathways of the histamine H1 receptor
New findings in pharmacological effects induced by antihistamines: from PET studies to knock-out mice
Discussion: Mechanisms of antihistamines
Non-H1-receptor effects of antihistamines
Effects of H1 antihistamines on adhesion molecules: a possible rationale for long-term treatment
Beyond the histamine receptor: effect of antihistamines on mast cells
H1-receptor antagonists: effects on leukocytes, myth or reality?
Effect of antihistamines on epithelial cells
Discussion: Beyond the histamine receptor
Experimental models in rhinitis
Clinical assessment of antihistamines in rhinitis
Experimental models in asthma
Assessment of antihistamine efficacy and potency
Is antihistamine (H1-receptor antagonist) therapy useful in clinical asthma?
Experimental models of skin inflammation
Assessment of urticaria and angio-oedema
Discussion: Antihistamines for allergic disorders
The metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes
Non-cardiac adverse effects of antihistamines (H1-receptor antagonists)
Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects
CNS effects of histamine H1 antagonists
Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation
The non-cardiac systemic side-effects of antihistamines: ebastine
Lack of behavioural toxicity of mizolastine: a review of the clinical pharmacology studies
The systemic safety of fexofenadine HCl
Discussion: The systemic side-effects of antihistamine
Arrhythmogenic mechanisms of non-sedating antihistamines
Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity
Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome
Cardiovascular profile of loratadine
A review of the cardiac systemic side-effects of antihistamines: ebastine
QT interval monitoring during clinical studies with mizolastine, a new H1 antihistamine
Cardiovascular safety of fexofenadine HCl
Prescription-event and other forms of epidemiological monitoring of side-effects in the UK
Spontaneous reporting of suspected adverse reactions to antihistamines: a national and international perspective
Discussion: Pharmacosurveillance
Discussion: Cardiac side-effects of antihistamines