Pathogenesis of Theiler's murine encephalomyelitis virus-induced disease


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Abstract

Theiler's murine encephalomyelitis virus (TMEV) is a member of the Cardiovirus genus of the Picornaviridae family. Interest in TMEV is at least partly related to the fact that the Daniels (DA) strain and other members of Theiler's original (TO) subgroup induce an inflammatory demyelinating disease in which the virus persists for the life of the mouse. This disease resembles multiple sclerosis because of the similar pathology and because the immune system seems to play an important role in both. The present review describes features of TMEV and the importance of both virus persistence as well as the immune system in the pathogenesis of DA virus-induced demyelinating disease. (Clin. Exp. Neuroimmunol. doi: 10.1111/j.1759-1961.2010.00008.x, 2010)

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