Comparison of wavefront aberrations in rabbit and human eyes


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Abstract

Background:The rabbit is one of the most common animal models used for preclinical safety evaluation of new cataract surgery and laser vision-correction technologies in ophthalmic research; however, the distributions of wavefront aberrations in rabbit eyes are unknown. The purpose of this study was to investigate the similarities and differences of wavefront aberrations between rabbit and human eyes.Methods:Monochromatic wavefront aberrations of left and right eyes of 12 rabbits and 12 human subjects with normal vision were measured by a commercial aberrometer (WaveScan Wavefront System, Abbott Medical Optics Inc, California, USA). Comparison of wavefront aberrations in rabbit and human eyes is based on a 6.0 mm pupil.Results:The rabbit eyes have an average spherical refraction of 1.51 ± 0.83 D and a cylindrical refraction of -1.03 ± 0.63 D. The average spherical refractive error of the human eyes used in this study was -2.03 ± 2.59 D with a cylindrical refraction of -1.27 ± 1.01 D. The average wavefront error root-mean-square (RMS) from higher-order aberrations is 0.34 μm in rabbits (6.0 mm pupil), which is higher compared to the wavefront error RMS value of human eyes (0.26 μm). The largest higher-order aberration in rabbit eyes is vertical coma (Z7, 0.19 ± 0.16 μm), whereas the largest higher-order aberration in human eyes is spherical aberration (Z12, 0.07 ± 0.13 μm). Wavefront error RMS, vertical coma and some higher-order aberrations are significantly correlated between the right and left rabbit eye.Conclusion:Compared to wavefront aberrations in the human eye measured in this study, the rabbit eye has less refractive error but larger higher-order aberrations both in wavefront error RMS and some higher-order aberration terms. Similar to human eyes, wavefront error and some higher-order aberrations are significantly correlated between the right and left rabbit eye.

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