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The non-predictable variability in the capability of sensory adaptation to rigid gas permeable (RGP) contact lenses (CLs) represents a considerable challenge for CL practitioners and patients when choosing this CL type. This study explored if lid margin sensitivity and general pain sensitivity at baseline may help predict experienced subjective comfort of RGP CL wear.For this prospective clinical cohort study, subjects filled in the Pain Sensitivity Questionnaire and lid margin sensitivity was measured at the lid wiper of the upper and lower lid at baseline, using the Cochet Bonnet aesthesiometer. RGP CL parameters were determined based on corneal topography, with additional use of fluorescein simulation. During the second visit, lid wiper sensitivity measurement was repeated and the RGP CLs were worn for 40 minutes. Upon removal of the CLs, lid wiper sensitivity measurement was repeated and spontaneous CL comfort was rated.Thirty-four subjects participated (mean age: 23.85 ± 5.39 years; 17 male). No correlation could be observed between the baseline lid margin sensitivity and spontaneous CL comfort (r = 0.013, p = 0.9417, upper lid; r = 0.016, p = 0.9277, lower lid). A decrease in lid margin sensitivity was obtained after CL wear (p = 0.0004, upper lid; p = 0.0001, lower lid). A good correlation was observed between Pain Sensitivity Questionnaire score and spontaneous CL comfort (r = 0.62, p = 0.0007).The results of this study suggest that lid margin sensitivity may not play an important role in spontaneous RGP CL comfort. The use of the Pain Sensitivity Questionnaire may well help select patients who are more likely to show good spontaneous tolerance of RGP CLs.