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In two elderly patients with ulcerative colitis, acute Guillain-Barre syndrome developed while the inflammatory bowel disease was in remission. The patients were treated with corticosteroids and recovered. Since both disorders are relatively uncommon, we suggest that the Guillain-Barre syndrome may have been causally related to the preexisting chronic inflammatory bowel disease. Guillain-Barre syndrome may be regarded as a possible extraintestinal complication of chronic ulcerative colitis.