Recurrent Urinary Tract Infections in Postmenopausal Women


    loading  Checking for direct PDF access through Ovid

Abstract

To evaluate factors associated with recurrent urinary tract infection (UTI) in postmenopausal women, we conducted a case-control study comparing 149 postmenopausal women referred to an infectious diseases outpatient clinic who had a history of recurrent UTI (case patients) with 53 age-matched women without a history of UTI (control patients). Each woman completed a questionnaire providing demographic data, history and clinical characteristics of prior infections, and information regarding risk factors for UTI. In addition, each patient underwent a gynecologic evaluation, renal ultrasound and urine flow studies, and blood group and secretor status testing. Three urologic factors—namely, incontinence (41% of case patients vs. 9.0% of control patients;P< .001), presence of a cystocele (19% vs. 0%;P< .001), and postvoiding residual urine (28% vs. 2.0%;P= .00008)—were all strongly associated with recurrent UTI. Multivariate analysis showed that urinary incontinence (odds ratio [OR], 5.79; 95% confidence interval [CI], 2.05-16.42;P= .0009), a history of UTI before menopause (OR, 4.85; 95% CI, 1.7-13.84;P= .003), and nonsecretor status (OR, 2.9; 95% CI, 1.28-6.25;P= .005) were most strongly associated with recurrent UTI in postmenopausal women. Prospective studies are needed to confirm these observations and to develop approaches for prevention.

    loading  Loading Related Articles