Novel Treatment of Meningitis Caused by Multidrug-Resistant Mycobacterium tuberculosis with Intrathecal Levofloxacin and Amikacin: Case Report

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We report the case of a 25-year-old HIV-negative man with disseminated multidrug-resistant tuberculosis (MDRTB), who—on a retreatment regimen—experienced total resolution of TB miliary disease, but progressive TB meningitis. Therefore, intrathecal treatment with amikacin and levofloxacin was instituted, with successful clinical and microbiological results.

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