Prolonged Perilesional Edema after Treatment of Parenchymal Neurocysticercosis: Methotrexate as a Corticosteroid-Sparing Agent

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Treatment of neurocysticercosis with larvicidal agents is commonly complicated by seizures and transient neurologic deficits as a result of the host immune response to dying cysts. We report a case in which treatment with high-dose praziquantel resulted in prolonged perilesional edema requiring use of corticosteroids and corticosteroid-sparing agents for >1 year, suggesting a role for methotrexate in the management of this condition.

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