Voriconazole Concentrations in the Cerebrospinal Fluid and Brain Tissue of Guinea Pigs and Immunocompromised Patients

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We characterized voriconazole concentrations in the cerebrospinal fluid (CSF) of immunocompetent guinea pigs and patients with invasive fungal infections. In animals, after receipt of oral doses of 4 or 10 mg/kg every 8 h, the mean ratios of CSF to plasma total and free drug concentration were 0.68 and 1.3, respectively. In humans, 1-10 h after receipt of voriconazole, the CSF concentrations ranged from 0.08 to 3.93 μg/mL, and the ratio of CSF to plasma concentration ranged from 0.22 to 1.0 (median, 0.46).

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