Tight Regulation of the Epstein-Barr Virus Setpoint: Interindividual Differences in Epstein-Barr Virus DNA Load Are Conserved after HIV Infection


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Abstract

Healthy individuals carry a constant number of Epstein-Barr virus-infected B cells in the peripheral blood over time. Here, we show that interindividual differences in Epstein-Barr virus DNA levels are maintained after HIV infection, providing evidence for the existence of an individual Epstein-Barr virus setpoint. Immune activation may contribute to the increase in this setpoint after human immunodeficiency virus seroconversion.

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