Endocannabinoids and the regulation of body fat: the smoke is clearing

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Endocannabinoids, endogenous ligands of cannabinoid receptor type 1 (CB1), have emerged as novel and important regulators of energy homeostasis. A report in this issue (see the related article beginning on page 423) demonstrates reduced body weight, fat mass, and appetite in CB1−/− mice. Examination of the underlying mechanisms reveals a dual role for endocannabinoids as they affect both appetite and peripheral lipolysis.

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