Come forth CD1d: Hsp110 in the regulation of intestinal epithelial CD1d expression


    loading  Checking for direct PDF access through Ovid

Abstract

CD1d, a nonclassical MHC class I-like molecule, is prominently expressed on intestinal epithelial cells and is thought to function in the regulation of intestinal intraepithelial lymphocyte activity. Hsp110, an abundant heat shock protein present in essentially all mammalian tissues, has now been shown to upregulate CD1d expression in colonic tissue culture cell lines (see the related article beginning on page 745). Might this abundant chaperone serve an autocrine function in the regulation of CD1d expression?

    loading  Loading Related Articles